NCTF 135 HA Skin Rejuvenation, Vitamin, Hydration, Pores | Fresh Code Clinic
NCTF 135 HA skin rejuvenation at Fresh Code Clinic.

What is NCTF 135 HA?

NCTF 135 HA is a skin quality treatment program that involves injecting a nourishing formula containing hyaluronic acid mixed with vitamins, minerals, and amino acids to treat dry, dull skin and fine wrinkles without altering facial features. This page explains what it is, what research supports it, and what questions you should ask before deciding to get this treatment at Fresh Code Clinic.

Key Takeaway

  • NCTF 135 HA is a non-crosslinked HA (Hyaluronic Acid) blend containing 59 other ingredients including vitamins, minerals, amino acids, and other substances. It is injected into the dermis to improve skin quality; it does not reshape the face.[4]
  • A 146-person RCT (producer-funded, unblinded participants) found improvement in fine lines and radiance compared to cream alone at 75 and 120 days.[1]
  • The pore size figures are based on a 20-person pilot study with no control group and no manufacturer-hired personnel, so they are merely trends.[2]
  • No studies comparing the ingredients to HA alone were found, so it is still unknown whether the added ingredients have a different effect than plain HA. Furthermore, there is no long-term data exceeding 120 days.
  • Most side effects are minor and disappear within 48 hours.[1] You should always ask to see the label and FDA registration number of the actual product being used before getting the injection.

What is NCTF 135 HA?

NCTF 135 HA is a biorevitalizing injectable substance from the Fillmed brand, used in aesthetic medicine clinics. Its main component is non-crosslinked hyaluronic acid (HA), blended with 59 other ingredients including 12 vitamins, 6 minerals, 5 nucleic acids, 24 amino acids, and 6 coenzymes, according to the distributor. The concentration of the HA is not specified.[4] Packaged in 3 ml vials.[4] According to the clinic, the product is from France.

Fillmed's NCTF 135 HA product.

This program doesn't focus on facial contouring or volume addition, but rather on skin quality such as hydration, smoothness, and the reduction of fine lines.

Regarding how things work "at the cellular level": The measurable results in the research included reduction in skin wrinkles, radiance, and hydration.[1] The mechanism by which vitamins and amino acids work in cells is a hypothesis based on research commissioned by the manufacturers and has not been directly tested.[2] Furthermore, among the sources examined, no studies were found comparing NCTF 135 HA to HA alone, so it remains unknown whether the added ingredients produce different results than regular HA.

What aspects of skin care does it help with, and who is it suitable for?

This program is designed for skin that requires non-surgical rejuvenation, such as:

  • Dry, dehydrated skin; makeup doesn't stay on.
  • Dull, tired-looking skin that lacks radiance.
  • Fine lines caused by dehydrated skin, such as around the eyes, neck, and décolletage.
  • Enlarged pores and uneven skin texture have been reported, but this is based on pilot studies without a control group, so it cannot be concluded that it works for everyone.[2]
  • For those who do not want extensive procedures or downtime, and for those who have already undergone laser or other treatments and wish to improve skin quality.

This program is not suitable for correcting deep wrinkles or reshaping the face. For volume enhancement, consult a doctor about fillers. The statement "suitable for all skin types" is not confirmed; a doctor will assess suitability on an individual basis, especially for those with a history of allergies, as the product contains multiple ingredients.[4]

Expected results and frequency of implementation.

workStudy modelThe results found.Limitations
Multicenter RCT (Fanian 2023)[1]A random 3:1 ratio was used to assign 146 participants to injections of NCTF 135HA combined with a cream, compared to cream alone, to the areas around the eyes, neck, and décolletage. Three injections were administered 3 weeks apart, and participants were followed for 120 days.At days 75 and 120, wrinkles were reduced and brightness scores improved compared to the cream group. Hydration increased 7 days after the last injection.The participants were not blinded (open-label). The control group consisted of the cream only, not a placebo injection. The manufacturer provided funding. Follow-up was for 120 days.
Pilot study (Grand-Vincent 2017)[2]Twenty women received five injections over 90 days; there was no control group.Wrinkle volume decreased by 32.91 TP3T, pore size decreased by 58.51 TP3T, and crow's feet wrinkle depth decreased by 43.31 TP3T. 17 out of 18 participants were satisfied.There is no control group, the sample size is small, the manufacturers hire, and some figures in the report are inconsistent.
Systematic review (Zhou 2025)[3]A total of 12 studies on HA skin injections were included (6 studies had sufficient data for analysis), not just those related to NCTF.HA injections improved hydration and radiance in the skin, but elasticity was not significantly different from the control group.This information pertains to HA skin injections in general, not specifically for this product. The author recommends further research.

summarize: One randomized, manufacturer-funded trial showed improvement in fine lines and radiance compared to using the cream alone within 4 months.[1] Regarding the conclusion that "skin becomes healthier in the long term," there is no supporting data because the follow-up studies conducted only lasted approximately 120 days.[1][2]

Frequency of performance: In an RCT (Randomized Controlled Trial), three injections were administered three weeks apart, at multiple points, with 0.05 ml per point, using a 4 mm long 32G needle. Two vials were used for the entire face and one vial for the neck or chest.[1] The pilot program involves five injections within 90 days.[2] The number of times and frequency used at the clinic were in accordance with the plan assessed by the doctor, and no information was found regarding continued treatment afterward.

Safety precautions and things to ask before getting vaccinated.

Side effects observed: In RCTs, most side effects were minor, resolved within 48 hours, and were related to the injection.[1] In the pilot study, minor skin rashes, bruising, and bleeding were observed. One participant withdrew after developing hives at the injection site.[2]

Product status: The distributor's trade name includes the word "CE," but the product page does not clearly classify it as a medical device and does not specify any contraindications.[4] Its status with the US FDA and the Thai FDA has not yet been verified.

  • Please show me the actual product box and label, as well as the FDA registration number.
  • Please disclose any history of drug or food allergies, pregnancy or breastfeeding, skin diseases, and medications you are currently taking.
  • Ask about the number of times, frequency, and technique the physician chose, compared to protocols in research studies.
  • If you experience a rash, severe swelling and redness, itching, or unusual pain after the injection, contact the clinic or consult a doctor.

Frequently Asked Questions about NCTF 135 HA

How does NCTF 135 HA differ from typical HA injections for skin brightening?

NCTF 135 HA contains non-crosslinked HA blended with vitamins, minerals, amino acids, and other ingredients, totaling 59 items according to the supplier's information.[4] However, in the sources tested, no studies comparing it to HA alone were found, so it is still unknown whether the added ingredients make a difference in results.

How many sessions are needed, and how long do the results last?

In an RCT, three injections were administered three weeks apart, and the outcomes were followed up for 120 days.[1] Longer-term data has not yet been examined. The appropriate number of sessions for each individual should be assessed by a doctor.

Does it really help to minimize pores and brighten the skin?

The pilot study reported smaller pores, but there was no control group and the manufacturer did not hire anyone.[2] The RCT (Random Control Test) reported better brightness scores than the cream group.[1] This should be viewed as an initial trend.

Do I need a recovery period? Are there any side effects?

In RCTs, most side effects were minor and resolved within 48 hours.[1] There may be minor redness, bruising, or bleeding, and one participant developed hives at the injection site during a pilot program.[2]

Is NCTF 135 HA suitable for all skin types?

That shouldn't be a definitive conclusion. Doctors will assess each individual, especially those with a history of allergies, skin conditions, pregnancy, or breastfeeding, who should be informed of their doctor before each injection.

Consult a specialist doctor.

Interested in NCTF 135 HA but unsure if it's right for your skin?

Consult with a doctor for free before making a decision. Inquire about the number of treatments, precautions, and products actually used via LINE @freshcodeclinic or at Fresh Code Clinic.

Add LINE @freshcodeclinic Consult a doctor.

  • Address: 19 Sukhumvit Soi 5, BTS Nana Exit 1 (Parking available)
  • telephone: 083-626-4264 / 02-253-2236
  • Opening hours: Open daily 11:00–20:00

References

  1. Fanian F, Deutsch JJ, Bousquet MT, et al. A hyaluronic acid-based micro-filler improves superficial wrinkles and skin quality: a randomized prospective controlled multicenter study. J Dermatolog Treat. 2023;34(1):2216323. doi:10.1080/09546634.2023.2216323. (RCT 146 people comparing NCTF 135HA in combination with anti-wrinkle cream versus cream alone; open-label; funded by manufacturer Laboratoires FILLMED; 120-day follow-up) https://pubmed.ncbi.nlm.nih.gov/37577796/
  2. Grand-Vincent A, Boisnic S, Salomon C, Prinderre P, Piccerelle P. Clinical Assessment of a Mesotherapy Formulation for Skin Rejuvenation in Healthy Volunteers. J Cosmet Dermatol Sci Appl. 2017;7(4):291-305. doi:10.4236/jcdsa.2017.74026. (Pilot study, 20 women, no control group; FILORGA, the manufacturer, commissioned the study, and one of the authors is the company's medical director; the report contains some inconsistent figures.) https://dx.doi.org/10.4236/jcdsa.2017.74026
  3. Zhou R, Yu M. The Effect of Local Hyaluronic Acid Injection on Skin Aging: A Systematic Review and Meta-Analysis. J Cosmet Dermatol. 2025;24(1):e16760. doi:10.1111/jocd.16760. (Includes 12 studies of general HA injections, not specific to NCTF; authors indicate no conflict of interest) https://pubmed.ncbi.nlm.nih.gov/39807700/
  4. DD Group. Fillmed NCTF 135HA CE (Code 600706): The distributor's product page lists 59 ingredients, including 12 vitamins, 6 minerals, 5 nucleic acids, 24 amino acids, 6 coenzymes, and other substances; the concentration of HA is not specified, and no contraindications are listed (distributor information, not regulatory agency documentation). https://www.ddgroup.com/facial-aesthetics/mesotherapy/600706--fillmed-nctf-135ha--ce

The information on this page is general and not medical advice. Treatment outcomes and suitability vary from person to person. Consult a doctor before making any decisions.